Relationship between serum HBV-RNA levels and intrahepatic viral as well as histologic activity markers in entecavir-treated patients
J Wang, Y Yu, G Li, C Shen, Z Meng, J Zheng, Y Jia… - Journal of …, 2018 - Elsevier
Background & Aims In diagnostics, serum hepatitis B virus (HBV)-RNA levels are valuable
when the HBV-DNA load in circulation is effectively suppressed by nucleos (t) ide analogue
(NUC) therapy. This study aimed to determine the intrahepatic viral replication activity
reflected in serum HBV-RNA and whether HBV-RNA contributes to liver histological
changes in patients treated with NUC. Methods A cross-sectional set of serum and liver
biopsy samples was obtained from patients treated with entecavir, who had undetectable …
when the HBV-DNA load in circulation is effectively suppressed by nucleos (t) ide analogue
(NUC) therapy. This study aimed to determine the intrahepatic viral replication activity
reflected in serum HBV-RNA and whether HBV-RNA contributes to liver histological
changes in patients treated with NUC. Methods A cross-sectional set of serum and liver
biopsy samples was obtained from patients treated with entecavir, who had undetectable …