Experimental simian varicella virus infection of St. Kitts vervet monkeys
WL Gray, RJ Williams, R Chang… - Journal of medical …, 1998 - Wiley Online Library
WL Gray, RJ Williams, R Chang, KF Soike
Journal of medical primatology, 1998•Wiley Online LibraryExperimental simian varicella virus (SVV) infection of St. Kitts vervet monkeys was evaluated
as an animal model to investigate human varicella‐zoster virus (VZV) infections. During the
incubation period, viremia disseminated infectious virus throughout the body via infected
peripheral blood lymphocytes (PBLs). A vesicular skin rash in the inguinal area, and on the
abdomen, extremities, and face appeared on day 7–10 postinfection. Necrosis and
hemorrhage in lung and liver tissues from acutely infected monkeys were evident upon …
as an animal model to investigate human varicella‐zoster virus (VZV) infections. During the
incubation period, viremia disseminated infectious virus throughout the body via infected
peripheral blood lymphocytes (PBLs). A vesicular skin rash in the inguinal area, and on the
abdomen, extremities, and face appeared on day 7–10 postinfection. Necrosis and
hemorrhage in lung and liver tissues from acutely infected monkeys were evident upon …
Experimental simian varicella virus (SVV) infection of St. Kitts vervet monkeys was evaluated as an animal model to investigate human varicella‐zoster virus (VZV) infections. During the incubation period, viremia disseminated infectious virus throughout the body via infected peripheral blood lymphocytes (PBLs). A vesicular skin rash in the inguinal area, and on the abdomen, extremities, and face appeared on day 7–10 postinfection. Necrosis and hemorrhage in lung and liver tissues from acutely infected monkeys were evident upon histologic analysis. Recovery from simian varicella was accompanied by a rise in the serum neutralizing antibody response to the virus. SVV latency was established in trigeminal ganglia of monkeys which resolved the acute infection. This study indicates that experimental SVV infection of St. Kitts vervets is a useful animal model to investigate SVV and VZV pathogenesis and to evaluate potential antiviral agents and vaccines.
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