[HTML][HTML] Lipopolysaccharide-driven Th2 cytokine production in macrophages is regulated by both MyD88 and TRAM

S Mukherjee, LY Chen, TJ Papadimos, S Huang… - Journal of Biological …, 2009 - ASBMB
Gram-negative bacterial lipopolysaccharide (LPS) activates macrophages by interacting
with Toll-like receptor 4 (TLR4) and triggers the production of various pro-inflammatory Th1
type (type 1) cytokines such as IFNγ, TNFα, and IL8. Though some recent studies cited
macrophages as potential sources for Th2 type (type 2) cytokines, little however is known
about the intracellular events that lead to LPS-induced type 2 cytokines in macrophages. To
understand the mechanisms by which LPS induces type 2 cytokine gene expression …