[HTML][HTML] Decreased cardiolipin synthesis corresponds with cytochromec release in palmitate-induced cardiomyocyte apoptosis

DB Ostrander, GC Sparagna, AA Amoscato… - Journal of Biological …, 2001 - ASBMB
Apoptosis has been identified recently as a component of many cardiac pathologies.
However, the potential triggers of programmed cell death in the heart and the involvement of
specific metabolic pathway (s) are less well characterized. Detachment of cytochrome c from
the mitochondrial inner membrane is a necessary first step for cytochrome c release into the
cytosol and initiation of apoptosis. The saturated long chain fatty acid, palmitate, induces
apoptosis in rat neonatal cardiomyocytes and diminishes content of the mitochondrial …