Distal axonopathy: one common type of neurotoxic lesion.

PS Spencer, HH Schaumburg - Environmental health …, 1978 - ehp.niehs.nih.gov
Neurotoxic chemicals commonly produce retrograde degeneration of the axons of long and
large nerve fibers in the central and peripheral nervous system. This produces a clinical
picture of polyneuropathy in man and animals in which sensory and motor disturbances
develop in the feet and hands then progress with time to the legs and arms. Distal
axonopathy, as the underlying pathologic process is termed, is one of four principal types of
neurotoxic diseases, the others including degeneration of neurons (neuronopathy), myelin …