Cardiolipins (CLs) are ancient and unusual dimeric phospholipids localized in the plasma
membrane of bacteria and in the inner mitochondrial membrane of eukaryotes. In
mitochondria, two types of asymmetries–trans-membrane and molecular–are essential
determinants of CL functions. In this review, we describe CL-based signaling mitochondrial
pathways realized via modulation of trans-membrane asymmetry and leading to
externalization and peroxidation of CLs in mitophagy and apoptosis, respectively. We …