Enhanced risk for Alzheimer disease in persons with type 2 diabetes and APOE ε4: the Cardiovascular Health Study Cognition Study
F Irie, AL Fitzpatrick, OL Lopez, LH Kuller… - Archives of …, 2008 - jamanetwork.com
Background Diabetes and the apolipoprotein E ε4 allele (APOEε4) increase the risk for
Alzheimer disease (AD). We hypothesize thatAPOEε4 may modify the risk for AD in
individuals with diabetes. Objective To examine the joint effect of type 2 diabetes
andAPOEε4 on the risk of AD, AD with vascular dementia (mixed AD), and vascular
dementia without AD. Design The Cardiovascular Health Study (CHS) Cognition Study
(1992-2000) is a prospective study designed to identify all existing and new cases of …
Alzheimer disease (AD). We hypothesize thatAPOEε4 may modify the risk for AD in
individuals with diabetes. Objective To examine the joint effect of type 2 diabetes
andAPOEε4 on the risk of AD, AD with vascular dementia (mixed AD), and vascular
dementia without AD. Design The Cardiovascular Health Study (CHS) Cognition Study
(1992-2000) is a prospective study designed to identify all existing and new cases of …