Prion protein as trans-interacting partner for neurons is involved in neurite outgrowth and neuronal survival
S Chen, A Mangé, L Dong, S Lehmann… - Molecular and Cellular …, 2003 - Elsevier
Many uncertainties remain regarding the physiological function of the prion protein PrP and
the consequences of its conversion into the pathological scrapie isoform in prion diseases.
Here, we show for the first time that different signal transduction pathways are involved in
neurite outgrowth and neuronal survival elicited by PrP in cell culture of primary neurons.
These pathways include the nonreceptor Src-related family member p59Fyn, PI3 kinase/Akt,
cAMP-dependent protein kinase A, and MAP kinase. Regulation of Bcl-2 and Bax …
the consequences of its conversion into the pathological scrapie isoform in prion diseases.
Here, we show for the first time that different signal transduction pathways are involved in
neurite outgrowth and neuronal survival elicited by PrP in cell culture of primary neurons.
These pathways include the nonreceptor Src-related family member p59Fyn, PI3 kinase/Akt,
cAMP-dependent protein kinase A, and MAP kinase. Regulation of Bcl-2 and Bax …