Attenuated TLR4/MAPK signaling in monocytes from patients with CRMO results in impaired IL-10 expression
SR Hofmann, H Morbach, T Schwarz, A Rösen-Wolff… - Clinical …, 2012 - Elsevier
Chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory bone disorder of
unknown origin. We previously demonstrated that monocytes from CRMO patients fail to
express the immune-modulatory cytokine interleukin‐10 (IL‐10) in a chromatin dependent
manner. Here, we demonstrate that attenuated extracellular-signal regulated kinase (ERK) 1
and 2 signaling in response to TLR4 activation results in failure to induce IL-10 expression
in monocytes from CRMO patients. Attenuated ERK1/2 activation results in 1) reduced levels …
unknown origin. We previously demonstrated that monocytes from CRMO patients fail to
express the immune-modulatory cytokine interleukin‐10 (IL‐10) in a chromatin dependent
manner. Here, we demonstrate that attenuated extracellular-signal regulated kinase (ERK) 1
and 2 signaling in response to TLR4 activation results in failure to induce IL-10 expression
in monocytes from CRMO patients. Attenuated ERK1/2 activation results in 1) reduced levels …