Chronic non-bacterial osteomyelitis is associated with impaired Sp1 signaling, reduced IL10 promoter phosphorylation, and reduced myeloid IL-10 expression
SR Hofmann, T Schwarz, JC Möller, H Morbach… - Clinical …, 2011 - Elsevier
Chronic non-bacterial osteomyelitis (CNO) is an auto-inflammatory disorder that affects the
skeletal system. Interleukin (IL-) 10 is an immune-modulatory cytokine that controls
inflammation, and limits inflammatory cytokine responses. Dysregulation of IL-10 expression
has been shown to result in autoimmune and infectious diseases. We investigated IL-10
expression by monocytic cells from CNO patients and controls. In response to stimulation
with LPS, IL-10 expression from CNO monocytes was reduced (p< 0.001). This was …
skeletal system. Interleukin (IL-) 10 is an immune-modulatory cytokine that controls
inflammation, and limits inflammatory cytokine responses. Dysregulation of IL-10 expression
has been shown to result in autoimmune and infectious diseases. We investigated IL-10
expression by monocytic cells from CNO patients and controls. In response to stimulation
with LPS, IL-10 expression from CNO monocytes was reduced (p< 0.001). This was …