[HTML][HTML] Oxidized phospholipid inhibition of toll-like receptor (TLR) signaling is restricted to TLR2 and TLR4: roles for CD14, LPS-binding protein, and MD2 as targets …
C Erridge, S Kennedy, CM Spickett, DJ Webb - Journal of Biological …, 2008 - ASBMB
The generation of reactive oxygen species is a central feature of inflammation that results in
the oxidation of host phospholipids. Oxidized phospholipids, such as 1-palmitoyl-2-
arachidonyl-sn-glycero-3-phosphorylcholine (OxPAPC), have been shown to inhibit
signaling induced by bacterial lipopeptide or lipopolysac-charide (LPS), yet the mechanisms
responsible for the inhibition of Toll-like receptor (TLR) signaling by OxPAPC remain
incompletely understood. Here, we examined the mechanisms by which OxPAPC inhibits …
the oxidation of host phospholipids. Oxidized phospholipids, such as 1-palmitoyl-2-
arachidonyl-sn-glycero-3-phosphorylcholine (OxPAPC), have been shown to inhibit
signaling induced by bacterial lipopeptide or lipopolysac-charide (LPS), yet the mechanisms
responsible for the inhibition of Toll-like receptor (TLR) signaling by OxPAPC remain
incompletely understood. Here, we examined the mechanisms by which OxPAPC inhibits …
