The relationship between mitochondrial function and walking performance in older adults with a wide range of physical function
Background Age related declines in walking performance may be partly attributable to
skeletal muscle mitochondrial dysfunction as mitochondria produce over 90% of ATP
needed for movement and the capacity for oxidative phosphorylation decreases with age.
Methods Participants were from two studies: an ancillary to the Lifestyle Interventions and
Independence for Elders (LIFE) Study (n= 33), which recruited lower functioning participants
(Short Physical Performance Battery [SPPB], 7.8±1.2), and the Study of Energy and Aging …
skeletal muscle mitochondrial dysfunction as mitochondria produce over 90% of ATP
needed for movement and the capacity for oxidative phosphorylation decreases with age.
Methods Participants were from two studies: an ancillary to the Lifestyle Interventions and
Independence for Elders (LIFE) Study (n= 33), which recruited lower functioning participants
(Short Physical Performance Battery [SPPB], 7.8±1.2), and the Study of Energy and Aging …