IL-36 in psoriasis
JE Towne, JE Sims - Current opinion in pharmacology, 2012 - Elsevier
Psoriasis is a common but severe skin disease with significant health consequences, both
physical and psychological. Evidence has emerged during the past several years pointing to
a key role for IL-36 in psoriasis. Overexpression of IL-36 in mouse skin leads to a disease
quite similar to human plaque psoriasis, and inhibition of IL-36 in human psoriatic skin
ameliorates the inflammation. Loss of the natural antagonist of IL-36, IL-36Ra, results in a
different, more severe skin disease known as pustular psoriasis. These effects are likely a …
physical and psychological. Evidence has emerged during the past several years pointing to
a key role for IL-36 in psoriasis. Overexpression of IL-36 in mouse skin leads to a disease
quite similar to human plaque psoriasis, and inhibition of IL-36 in human psoriatic skin
ameliorates the inflammation. Loss of the natural antagonist of IL-36, IL-36Ra, results in a
different, more severe skin disease known as pustular psoriasis. These effects are likely a …