Photoaging and skin cancer: Is the inflammasome the missing link?
F Awad, E Assrawi, C Louvrier, C Jumeau… - Mechanisms of Ageing …, 2018 - Elsevier
Photoaging and epithelial skin tumorigenesis are complex processes triggered mainly by
UV radiation from chronic sun exposure. This leads to DNA damage and reactive oxygen
species (ROS) production, which initiate an inflammatory response that alters cell structure
and function. Changes in cell homeostasis and ROS production activate intracellular
multiprotein platforms called inflammasomes. Inflammasomes nucleate around cytoplasmic
receptors mainly of the NLR (nucleotide-binding domain and leucine-rich repeat) family and …
UV radiation from chronic sun exposure. This leads to DNA damage and reactive oxygen
species (ROS) production, which initiate an inflammatory response that alters cell structure
and function. Changes in cell homeostasis and ROS production activate intracellular
multiprotein platforms called inflammasomes. Inflammasomes nucleate around cytoplasmic
receptors mainly of the NLR (nucleotide-binding domain and leucine-rich repeat) family and …