Structure and function of the epidermal barrier

RR Wickett, MO Visscher - American journal of infection control, 2006 - Elsevier
The skin is divided into 2 main structural layers: the epidermis and the dermis. The
epidermis is generally considered to be subdivided into 5 separate strata: basal, spinous,
granular, lucid, and corneum. The vital barrier function of the skin resides primarily in the top
stratum of the epidermis, the stratum corneum (SC). The SC is the barrier to the passive
diffusion of water out of the skin, allowing us to live in air without suffering from dehydration,
and is the barrier to other molecules including irritants into the skin. The epidermis also has …