Toll‐like receptors and skin

AT Ermertcan, F Öztürk… - Journal of the European …, 2011 - Wiley Online Library
AT Ermertcan, F Öztürk, K Gündüz
Journal of the European Academy of Dermatology and Venereology, 2011Wiley Online Library
Toll‐like receptors are important pattern recognition receptors which have key roles in both
innate and adaptive immune responses. They are strongly associated with the pathogenesis
of inflammatory and autoimmune diseases. Furthermore, Toll‐like receptors have also been
implicated in the pathogenesis of several skin diseases such as skin infections, psoriasis,
acne vulgaris, lichen planus, Behçet's disease, leprosy, syphilis, Lyme disease, atopic
dermatitis and allergic contact dermatitis, mycosis fungoides, non‐melanoma skin cancers …
Abstract
Toll‐like receptors are important pattern recognition receptors which have key roles in both innate and adaptive immune responses. They are strongly associated with the pathogenesis of inflammatory and autoimmune diseases. Furthermore, Toll‐like receptors have also been implicated in the pathogenesis of several skin diseases such as skin infections, psoriasis, acne vulgaris, lichen planus, Behçet’s disease, leprosy, syphilis, Lyme disease, atopic dermatitis and allergic contact dermatitis, mycosis fungoides, non‐melanoma skin cancers and melanoma. In this manuscript, the structure and functions of Toll‐like receptors in immune responses, their impact on skin diseases and recent advances on therapeutic usage have been reviewed.
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