Psoriasis pathogenesis and the development of novel targeted immune therapies
JE Hawkes, TC Chan, JG Krueger - Journal of Allergy and Clinical …, 2017 - Elsevier
Psoriasis is caused by a complex interplay between the immune system, psoriasis-
associated susceptibility loci, autoantigens, and multiple environmental factors. Over the last
2 decades, research has unequivocally shown that psoriasis represents a bona fide T cell–
mediated disease primarily driven by pathogenic T cells that produce high levels of IL-17 in
response to IL-23. The discovery of the central role for the IL-23/type 17 T-cell axis in the
development of psoriasis has led to a major paradigm shift in the pathogenic model for this …
associated susceptibility loci, autoantigens, and multiple environmental factors. Over the last
2 decades, research has unequivocally shown that psoriasis represents a bona fide T cell–
mediated disease primarily driven by pathogenic T cells that produce high levels of IL-17 in
response to IL-23. The discovery of the central role for the IL-23/type 17 T-cell axis in the
development of psoriasis has led to a major paradigm shift in the pathogenic model for this …