Innate recognition of microbial products and danger molecules by monocytes and
macrophages has been well established; this is mediated primarily by pattern-recognition
receptors and is central to the activation of innate and adaptive immune cells required for
productive immunity. Whether monocytes and macrophages are equipped with an
allorecognition system that allows them to respond directly to allogeneic grafts is a topic of
much debate. Recent studies provide compelling evidence that these cells can recognize …