Expanding the spectrum of malignant change in schwannomas: epithelioid malignant change, epithelioid malignant peripheral nerve sheath tumor, and epithelioid …

ME McMenamin, CDM Fletcher - The American journal of surgical …, 2001 - journals.lww.com
Schwannomas (neurilemmomas) rarely undergo malignant change, most often in the form of
either malignant peripheral nerve sheath tumor (MPNST) or angiosarcoma. We characterize
the clinical features and the histopathologic spectrum of 17 schwannomas with evidence of
malignant change. The study group comprised 7 males and 10 females with an age range of
16 to 76 years,(median, 40 yrs). None of the patients had neurofibromatosis. Lesions ranged
in size from 0.6 to 10.5 cm (median, 4.0 cm) and arose mainly in the limbs/limb girdles (7 …