[HTML][HTML] Neutrophil heterogeneity as therapeutic opportunity in immune-mediated disease

R Grieshaber-Bouyer, PA Nigrovic - Frontiers in immunology, 2019 - frontiersin.org
Frontiers in immunology, 2019frontiersin.org
Neutrophils are versatile innate effector cells essential for immune defense but also
responsible for pathologic inflammation. This dual role complicates therapeutic targeting.
However, neither neutrophils themselves nor the mechanisms they employ in different forms
of immune responses are homogeneous, offering possibilities for selective intervention.
Here we review heterogeneity within the neutrophil population as well as in the pathways
mediating neutrophil recruitment to inflamed tissues with a view to outlining opportunities for …
Neutrophils are versatile innate effector cells essential for immune defense but also responsible for pathologic inflammation. This dual role complicates therapeutic targeting. However, neither neutrophils themselves nor the mechanisms they employ in different forms of immune responses are homogeneous, offering possibilities for selective intervention. Here we review heterogeneity within the neutrophil population as well as in the pathways mediating neutrophil recruitment to inflamed tissues with a view to outlining opportunities for therapeutic manipulation in inflammatory disease.
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