MeCP2 deficiency enhances glutamate release through NF-κB signaling in myeloid derived cells

CM O'Driscoll, WE Kaufmann, JP Bressler - Journal of neuroimmunology, 2013 - Elsevier
The signaling pathway involved in regulating glutamate release was investigated.
Glutaminase mRNA levels were higher in microglia isolated from mice treated with
lipopolysaccharide. Pam3CSK and lipopolysaccharide stimulated glutamate release in
neonatal mouse microglia cultures, which was attenuated by NF-κB inhibitors. Higher levels
of glutaminase mRNA and glutamate release were observed in human peripheral blood
mononuclear cells made MeCP2 deficient with MeCP2 shRNA, which was blocked by NF-κB …