Late endocytic compartments include late endosomes, lysosomes and hybrid organelles. In
the acidic lumen, cargo material derived from endocytosed and phagocytosed extracellular
material and autophagy-derived intracellular material is degraded. In the event of lysosomal
membrane permeabilization (LMP), the function of endo/lysosomal compartment is affected
and the luminal contents are released into the cytosol to various extents. LMP can be a
result of osmotic lysis or direct membranolytic activity of the compounds that accumulate in …