[HTML][HTML] Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases
KA Glenn, RF Nelson, HM Wen, AJ Mallinger… - Journal of biological …, 2008 - ASBMB
Post-translational modification of proteins regulates many cellular processes. Some
modifications, including N-linked glycosylation, serve multiple functions. For example, the
attachment of N-linked glycans to nascent proteins in the endoplasmic reticulum facilitates
proper folding, whereas retention of high mannose glycans on misfolded glycoproteins
serves as a signal for retrotranslocation and ubiquitin-mediated proteasomal degradation.
Here we examine the substrate specificity of the only family of ubiquitin ligase subunits …
modifications, including N-linked glycosylation, serve multiple functions. For example, the
attachment of N-linked glycans to nascent proteins in the endoplasmic reticulum facilitates
proper folding, whereas retention of high mannose glycans on misfolded glycoproteins
serves as a signal for retrotranslocation and ubiquitin-mediated proteasomal degradation.
Here we examine the substrate specificity of the only family of ubiquitin ligase subunits …