A role for AQP5 in activation of TRPV4 by hypotonicity: concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery
X Liu, B Bandyopadhyay, T Nakamoto, B Singh… - Journal of Biological …, 2006 - ASBMB
Regulation of cell volume in response to changes in osmolarity is critical for cell function and
survival. However, the molecular basis of osmosensation and regulation of cell volume are
not clearly understood. We have examined the mechanism of regulatory volume decrease
(RVD) in salivary gland cells and report a novel association between osmosensing TRPV4
(transient receptor potential vanalloid 4) and AQP5 (aquaporin 5), which is required for
regulating water permeability and cell volume. Exposure of salivary gland cells and acini to …
survival. However, the molecular basis of osmosensation and regulation of cell volume are
not clearly understood. We have examined the mechanism of regulatory volume decrease
(RVD) in salivary gland cells and report a novel association between osmosensing TRPV4
(transient receptor potential vanalloid 4) and AQP5 (aquaporin 5), which is required for
regulating water permeability and cell volume. Exposure of salivary gland cells and acini to …
