A simple phenylalanine method for detecting phenylketonuria in large populations of newborn infants
R Guthrie, A Susi - Pediatrics, 1963 - publications.aap.org
A new method is described for rapid and economical screening of large numbers of hospital
nursery infants for elevation in blood phenylalanine associated with phenylketonuria.
Results are presented for 682 infants, 96% of whom were 4 days of age. None of the blood
phenylalanine values were found to be as high as 4 mg/100 ml, and only 8% were above 2
mg/100 ml. These values appear to be in agreement with values obtained by other methods,
and indicate that a very low rate of" false-positives" will be encountered during screening of …
nursery infants for elevation in blood phenylalanine associated with phenylketonuria.
Results are presented for 682 infants, 96% of whom were 4 days of age. None of the blood
phenylalanine values were found to be as high as 4 mg/100 ml, and only 8% were above 2
mg/100 ml. These values appear to be in agreement with values obtained by other methods,
and indicate that a very low rate of" false-positives" will be encountered during screening of …
