Whereas the impact of early-treated phenylketonuria (ETPKU) on cortical white matter is well
documented, relatively little is known regarding the potential impact of this metabolic
disorder on deep gray matter structures such as the basal ganglia. The current study used
high-resolution (1mm3) magnetic resonance imaging to investigate bilateral basal ganglia
structures (ie, putamen, caudate nucleus, and nucleus accumbens) in a sample of 13
individuals with ETPKU and a demographically-matched sample of 13 neurologically intact …