Morphometric analysis of gray matter integrity in individuals with early-treated phenylketonuria
SE Christ, MH Price, KE Bodner, C Saville… - Molecular genetics and …, 2016 - Elsevier
The most widely-reported neurologic finding in individuals with early-treated
phenylketonuria (PKU) is abnormality in the white matter of the brain. In contrast, much less
is known regarding the impact of PKU on cortical gray matter (GM) structures. Presently, we
applied advanced morphometric methods to the analysis of high-resolution structural MRI
images from a sample of 19 individuals with early-treated PKU and an age-and gender-
matched comparison group of 22 healthy individuals without PKU. Data analysis revealed …
phenylketonuria (PKU) is abnormality in the white matter of the brain. In contrast, much less
is known regarding the impact of PKU on cortical gray matter (GM) structures. Presently, we
applied advanced morphometric methods to the analysis of high-resolution structural MRI
images from a sample of 19 individuals with early-treated PKU and an age-and gender-
matched comparison group of 22 healthy individuals without PKU. Data analysis revealed …
