Different strokes for different folks: the rich diversity of animal models of focal cerebral ischemia

DW Howells, MJ Porritt, SSJ Rewell… - Journal of Cerebral …, 2010 - journals.sagepub.com
DW Howells, MJ Porritt, SSJ Rewell, V O'collins, ES Sena, HB Van Der Worp, RJ Traystman…
Journal of Cerebral Blood Flow & Metabolism, 2010journals.sagepub.com
No single animal model is able to encompass all of the variables known to affect human
ischemic stroke. This review highlights the major strengths and weaknesses of the most
commonly used animal models of acute ischemic stroke in the context of matching model
and experimental aim. Particular emphasis is placed on the relationships between outcome
and underlying vascular variability, physiologic control, and use of models of comorbidity.
The aim is to provide, for novice and expert alike, an overview of the key controllable …
No single animal model is able to encompass all of the variables known to affect human ischemic stroke. This review highlights the major strengths and weaknesses of the most commonly used animal models of acute ischemic stroke in the context of matching model and experimental aim. Particular emphasis is placed on the relationships between outcome and underlying vascular variability, physiologic control, and use of models of comorbidity. The aim is to provide, for novice and expert alike, an overview of the key controllable determinants of experimental stroke outcome to help ensure the most effective application of animal models to translational research.
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