Implication of protein tyrosine phosphatase SHP-1 in cancer-related signaling pathways

Y Sharma, A Ahmad, S Bashir, A Elahi, F Khan - Future Oncology, 2016 - Future Medicine
Future Oncology, 2016Future Medicine
The altered expression of SHP-1 (SH2 domain-containing protein tyrosine phosphatase) as
a consequence of promoter hypermethylation or mutations has evidently been linked to
cancer development. The notion of being a cancer drug target is conceivable as SHP-1
negatively regulates cell cycle and inflammatory pathways which are an inevitable part of
oncogenic transformation. In the present review, we try to critically analyze the role of SHP-1
in cancer progression via regulating the above mentioned pathways with the major …
The altered expression of SHP-1 (SH2 domain-containing protein tyrosine phosphatase) as a consequence of promoter hypermethylation or mutations has evidently been linked to cancer development. The notion of being a cancer drug target is conceivable as SHP-1 negatively regulates cell cycle and inflammatory pathways which are an inevitable part of oncogenic transformation. In the present review, we try to critically analyze the role of SHP-1 in cancer progression via regulating the above mentioned pathways with the major emphasis on cell cycle components and JAK/STAT pathway, commencing with the SHP-1 biology in immune cell signaling. Lastly, we have provided the future directions for researchers to encourage SHP-1 as a prognostic marker and curative target for this debilitating disease called as cancer.
Future Medicine