Preventive or late administration of anti-NGF therapy attenuates tumor-induced nerve sprouting, neuroma formation, and cancer pain
JM Jimenez-Andrade, JR Ghilardi, G Castaneda-Corral… - Pain, 2011 - Elsevier
Early, preemptive blockade of nerve growth factor (NGF)/tropomyosin receptor kinase A
(TrkA) attenuates tumor-induced nerve sprouting and bone cancer pain. A critical
unanswered question is whether late blockade of NGF/TrkA can attenuate cancer pain once
NGF-induced nerve sprouting and neuroma formation has occurred. By means of a mouse
model of prostate cancer-induced bone pain, anti-NGF was either administered
preemptively at day 14 after tumor injection when nerve sprouting had yet to occur, or late at …
(TrkA) attenuates tumor-induced nerve sprouting and bone cancer pain. A critical
unanswered question is whether late blockade of NGF/TrkA can attenuate cancer pain once
NGF-induced nerve sprouting and neuroma formation has occurred. By means of a mouse
model of prostate cancer-induced bone pain, anti-NGF was either administered
preemptively at day 14 after tumor injection when nerve sprouting had yet to occur, or late at …