A tryptophan metabolite of the skin microbiota attenuates inflammation in patients with atopic dermatitis through the aryl hydrocarbon receptor
J Yu, Y Luo, Z Zhu, Y Zhou, L Sun, J Gao, J Sun… - Journal of Allergy and …, 2019 - Elsevier
Background Previous studies have revealed significant alterations in the skin microbiota of
patients with atopic dermatitis (AD) not only in diversity and composition but also in function,
and the tryptophan (Trp) metabolic pathway is attenuated in the skin microbiota of patients
with AD. Objective We sought to assess Trp metabolites on the skin surfaces of patients with
AD and to explore the function of the microbial Trp metabolites in skin inflammation in
patients with AD. Methods A gel-patch method was developed to collect metabolites on the …
patients with atopic dermatitis (AD) not only in diversity and composition but also in function,
and the tryptophan (Trp) metabolic pathway is attenuated in the skin microbiota of patients
with AD. Objective We sought to assess Trp metabolites on the skin surfaces of patients with
AD and to explore the function of the microbial Trp metabolites in skin inflammation in
patients with AD. Methods A gel-patch method was developed to collect metabolites on the …