Serum amyloid A is found on apoB‐containing lipoproteins in obese humans with diabetes
A Jahangiri, PG Wilson, T Hou, A Brown, VL King… - …, 2013 - Wiley Online Library
A Jahangiri, PG Wilson, T Hou, A Brown, VL King, LR Tannock
Obesity, 2013•Wiley Online LibraryObjective: In murine models of obesity/diabetes, there is an increase in plasma serum
amyloid A (SAA) levels along with redistribution of SAA from high‐density lipoprotein (HDL)
to apolipoprotein B (apoB)‐containing lipoprotein particles, namely, low‐density lipoprotein
and very low‐density lipoprotein. The goal of this study was to determine if obesity is
associated with similar SAA lipoprotein redistribution in humans. Design and Methods:
Three groups of obese individuals were recruited from a weight loss clinic: healthy obese …
amyloid A (SAA) levels along with redistribution of SAA from high‐density lipoprotein (HDL)
to apolipoprotein B (apoB)‐containing lipoprotein particles, namely, low‐density lipoprotein
and very low‐density lipoprotein. The goal of this study was to determine if obesity is
associated with similar SAA lipoprotein redistribution in humans. Design and Methods:
Three groups of obese individuals were recruited from a weight loss clinic: healthy obese …
Objective
In murine models of obesity/diabetes, there is an increase in plasma serum amyloid A (SAA) levels along with redistribution of SAA from high‐density lipoprotein (HDL) to apolipoprotein B (apoB)‐containing lipoprotein particles, namely, low‐density lipoprotein and very low‐density lipoprotein. The goal of this study was to determine if obesity is associated with similar SAA lipoprotein redistribution in humans.
Design and Methods
Three groups of obese individuals were recruited from a weight loss clinic: healthy obese (n = 14), metabolic syndrome (MetS) obese (n = 8), and obese with type 2 diabetes (n = 6). Plasma was separated into lipoprotein fractions by fast protein liquid chromatography, and SAA was measured in lipid fractions using enzyme‐linked immunosorbent assay and Western blotting.
Results
Only the obese diabetic group had SAA detectable in apoB‐containing lipoproteins, and SAA reverted back to HDL with active weight loss.
Conclusions
In human subjects, SAA is found in apoB‐containing lipoprotein particles only in obese subjects with type 2 diabetes, but not in healthy obese or obese subjects with MetS.
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