[HTML][HTML] Serum amyloid A3 is a high density lipoprotein-associated acute-phase protein
LR Tannock, MC De Beer, A Ji, P Shridas… - Journal of lipid …, 2018 - ASBMB
Serum amyloid A (SAA) is a family of acute-phase reactants. Plasma levels of human
SAA1/SAA2 (mouse SAA1. 1/2.1) can increase≥ 1,000-fold during an acute-phase
response. Mice, but not humans, express a third relatively understudied SAA isoform, SAA3.
We investigated whether mouse SAA3 is an HDL-associated acute-phase SAA. Quantitative
RT-PCR with isoform-specific primers indicated that SAA3 and SAA1. 1/2.1 are induced
similarly in livers (∼ 2,500-fold vs.∼ 6,000-fold, respectively) and fat (∼ 400-fold vs.∼ 100 …
SAA1/SAA2 (mouse SAA1. 1/2.1) can increase≥ 1,000-fold during an acute-phase
response. Mice, but not humans, express a third relatively understudied SAA isoform, SAA3.
We investigated whether mouse SAA3 is an HDL-associated acute-phase SAA. Quantitative
RT-PCR with isoform-specific primers indicated that SAA3 and SAA1. 1/2.1 are induced
similarly in livers (∼ 2,500-fold vs.∼ 6,000-fold, respectively) and fat (∼ 400-fold vs.∼ 100 …