Spinal glutamate uptake is critical for maintaining normal sensory transmission in rat spinal cord

WJ Liaw, RL Stephens Jr, BC Binns, Y Chu, JP Sepkuty… - Pain, 2005 - Elsevier
Glutamate is a major excitatory neurotransmitter in primary afferent terminals and is critical
for normal spinal excitatory synaptic transmission. However, little is known about the
regulation of synaptically released glutamate in the spinal cord under physiologic
conditions. The sodium-dependent, high-affinity glutamate transporters are the primary
mechanism for the clearance of synaptically released glutamate. In the present study, we
found that intrathecal injection of glutamate transporter blockers dl-threo-β …