The biologic clock: the mitochondria?
D Harman - Journal of the American Geriatrics Society, 1972 - Wiley Online Library
D Harman
Journal of the American Geriatrics Society, 1972•Wiley Online LibraryThe author suggests that the maximal life span of a given mammalian species is largely an
expression of genetic control over the rate of oxygen utilization. The latter determines the
rate of accumulation of mitochondrial damage produced by free radical reactions, the rate
increasing with the rate of oxygen consumption, which ultimately causes death.
expression of genetic control over the rate of oxygen utilization. The latter determines the
rate of accumulation of mitochondrial damage produced by free radical reactions, the rate
increasing with the rate of oxygen consumption, which ultimately causes death.
Abstract
The author suggests that the maximal life span of a given mammalian species is largely an expression of genetic control over the rate of oxygen utilization. The latter determines the rate of accumulation of mitochondrial damage produced by free radical reactions, the rate increasing with the rate of oxygen consumption, which ultimately causes death.
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