[HTML][HTML] Morphologic patterns associated with BRCA1 and BRCA2 genotype in ovarian carcinoma
RA Soslow, G Han, KJ Park, K Garg, N Olvera… - Modern pathology, 2012 - Elsevier
This study was undertaken with the hypothesis that certain common morphologic features of
ovarian carcinomas are predictably associated with BRCA1 and BRCA2 deficiencies. We
selected 43 high-grade serous carcinomas diagnosed at Memorial Sloan-Kettering Cancer
Center that were studied as part of The Cancer Genome Atlas pilot project. In addition to 12
randomly selected nonfamilial BRCA-unassociated cases, all 31 Memorial Sloan-Kettering
Cancer Center cases with BRCA1 or BRCA2 abnormality were included (n= 43). Slides …
ovarian carcinomas are predictably associated with BRCA1 and BRCA2 deficiencies. We
selected 43 high-grade serous carcinomas diagnosed at Memorial Sloan-Kettering Cancer
Center that were studied as part of The Cancer Genome Atlas pilot project. In addition to 12
randomly selected nonfamilial BRCA-unassociated cases, all 31 Memorial Sloan-Kettering
Cancer Center cases with BRCA1 or BRCA2 abnormality were included (n= 43). Slides …