[HTML][HTML] Hepatic accumulation of Hedgehog-reactive progenitors increases with severity of fatty liver damage in mice
SV Fleig, SS Choi, L Yang, Y Jung, A Omenetti… - Laboratory …, 2007 - Elsevier
Progenitors regenerate fatty livers but the mechanisms involved are uncertain. The
Hedgehog pathway regulates mesendodermal progenitors and modulates mesenchymal–
epithelial interactions during tissue remodeling. To determine if Hedgehog signaling
increases in liver progenitors during fatty liver injury, we compared expression of Hedgehog
ligands and target genes across a spectrum of injury. Leptin-deficient ob/ob mice with fatty
livers and their healthy lean littermates were studied before and after exposure to the …
Hedgehog pathway regulates mesendodermal progenitors and modulates mesenchymal–
epithelial interactions during tissue remodeling. To determine if Hedgehog signaling
increases in liver progenitors during fatty liver injury, we compared expression of Hedgehog
ligands and target genes across a spectrum of injury. Leptin-deficient ob/ob mice with fatty
livers and their healthy lean littermates were studied before and after exposure to the …