Expression of IL-4 receptor α on smooth muscle cells is not necessary for development of experimental allergic asthma
F Kirstein, WGC Horsnell, DA Kuperman… - Journal of Allergy and …, 2010 - Elsevier
BACKGROUND: Airflow in the lungs of patients with allergic asthma is impaired by
excessive mucus production and airway smooth muscle contractions. Elevated levels of the
cytokines IL-4 and IL-13 are associated with this pathology. In vitro studies have suggested
that IL-4 receptor α (IL-4Rα) signaling on smooth muscle cells is critical for airway
inflammation and airway hyperresponsiveness. OBJECTIVE: To define the contribution of IL-
4 and IL-13 to the onset of asthmatic pathology, the role of their key receptor IL-4Rα in …
excessive mucus production and airway smooth muscle contractions. Elevated levels of the
cytokines IL-4 and IL-13 are associated with this pathology. In vitro studies have suggested
that IL-4 receptor α (IL-4Rα) signaling on smooth muscle cells is critical for airway
inflammation and airway hyperresponsiveness. OBJECTIVE: To define the contribution of IL-
4 and IL-13 to the onset of asthmatic pathology, the role of their key receptor IL-4Rα in …
