Allergic airway disease is unaffected by the absence of IL-4Rα–dependent alternatively activated macrophages
NE Nieuwenhuizen, F Kirstein, J Jayakumar… - Journal of Allergy and …, 2012 - Elsevier
BACKGROUND: Markers of alternatively activated macrophages (AAMs) are upregulated in
the lungs of asthmatic patients and in mice with allergic airway disease. AAMs are thought to
contribute to the pathogenesis of allergic airway disease by virtue of their decreased NO
production and increased production of proline and polyamines, which are important in the
synthesis of connective tissues such as collagen. OBJECTIVE: We aimed to define the role
of AAMs in the pathogenesis of allergic airway disease. METHODS: The IL-4 receptor alpha …
the lungs of asthmatic patients and in mice with allergic airway disease. AAMs are thought to
contribute to the pathogenesis of allergic airway disease by virtue of their decreased NO
production and increased production of proline and polyamines, which are important in the
synthesis of connective tissues such as collagen. OBJECTIVE: We aimed to define the role
of AAMs in the pathogenesis of allergic airway disease. METHODS: The IL-4 receptor alpha …