Background Tight junctions (TJs) form a barrier on the apical side of neighboring epithelial
cells in the bronchial mucosa. Changes in their integrity might play a role in asthma
pathogenesis by enabling the paracellular influx of allergens, toxins, and microbes to the
submucosal tissue. Objective The regulation of bronchial epithelial TJs by TH 2 cells and
their cytokines and their involvement in epigenetic regulation of barrier function were
investigated. Methods The expression, regulation, and function of TJs were determined in air …