IL-4 production by group 2 innate lymphoid cells promotes food allergy by blocking regulatory T-cell function
Background Food allergy is a major health issue, but its pathogenesis remains obscure.
Group 2 innate lymphoid cells (ILC2s) promote allergic inflammation. However their role in
food allergy is largely unknown. Objective We sought to investigate the role of ILC2s in food
allergy. Methods Food allergy–prone mice with a gain-of-function mutation in the IL-4
receptor α chain (Il4raF709) were orally sensitized with food allergens, and the ILC2
compartment was analyzed. The requirement for ILC2s in food allergy was investigated by …
Group 2 innate lymphoid cells (ILC2s) promote allergic inflammation. However their role in
food allergy is largely unknown. Objective We sought to investigate the role of ILC2s in food
allergy. Methods Food allergy–prone mice with a gain-of-function mutation in the IL-4
receptor α chain (Il4raF709) were orally sensitized with food allergens, and the ILC2
compartment was analyzed. The requirement for ILC2s in food allergy was investigated by …