IL-33 dysregulates regulatory T cells and impairs established immunologic tolerance in the lungs
Background Airway exposure to environmental antigens generally leads to immunologic
tolerance. A fundamental question remains: Why is airway tolerance compromised in
patients with allergic airway diseases? IL-33 promotes innate and adaptive type 2 immunity
and might provide the answer to this question. Objective The goal of this study was to
investigate the roles played by IL-33 in altering regulatory T (Treg) cells in the lungs and in
affecting previously established airway immunologic tolerance. Methods We analyzed CD4+ …
tolerance. A fundamental question remains: Why is airway tolerance compromised in
patients with allergic airway diseases? IL-33 promotes innate and adaptive type 2 immunity
and might provide the answer to this question. Objective The goal of this study was to
investigate the roles played by IL-33 in altering regulatory T (Treg) cells in the lungs and in
affecting previously established airway immunologic tolerance. Methods We analyzed CD4+ …