[HTML][HTML] BK polyomavirus-specific cellular immune responses are age-dependent and strongly correlate with phases of virus replication
T Schmidt, C Adam, HH Hirsch, MWW Janssen… - American Journal of …, 2014 - Elsevier
BK polyomavirus (BKPyV) infection is widespread and typically asymptomatic during
childhood, but may cause nephropathy in kidney transplant recipients. However, there is
only limited knowledge on BKPyV-specific immunity in children and adults, and its role in
BKPyV-replication and disease posttransplant. We therefore characterized BKPyV-specific
immunity from 122 immunocompetent individuals (1–84 years), 38 adult kidney recipients
with (n= 14) and without BKPyV-associated complications (n= 24), and 25 hemodialysis …
childhood, but may cause nephropathy in kidney transplant recipients. However, there is
only limited knowledge on BKPyV-specific immunity in children and adults, and its role in
BKPyV-replication and disease posttransplant. We therefore characterized BKPyV-specific
immunity from 122 immunocompetent individuals (1–84 years), 38 adult kidney recipients
with (n= 14) and without BKPyV-associated complications (n= 24), and 25 hemodialysis …