Biphasic developmental changes in Ca2+/calmodulin-dependent proteins in R6/2 Huntington's disease mice
WA Deckel, R Elder, G Fuhrer - Neuroreport, 2002 - journals.lww.com
Widespread disturbances in calcium-dependent proteins are reported both in humans with
advanced Huntington's disease (HD) and in symptomatic HD transgenic mice. Using a HD
mouse model transgenic for exon 1 of the abnormal gene (eg the Bates R6/2 mouse), we
found increased expression of calmodulin kinase IV and neuronal nitric oxide synthase
(NOS) in 3-week-old presymptomatic HD mice striatum and cortex. Conversely, reduced
expression was found at 6 weeks (early symptom onset) and 11 weeks (advanced disease) …
advanced Huntington's disease (HD) and in symptomatic HD transgenic mice. Using a HD
mouse model transgenic for exon 1 of the abnormal gene (eg the Bates R6/2 mouse), we
found increased expression of calmodulin kinase IV and neuronal nitric oxide synthase
(NOS) in 3-week-old presymptomatic HD mice striatum and cortex. Conversely, reduced
expression was found at 6 weeks (early symptom onset) and 11 weeks (advanced disease) …