Several transcription factors are present at the synapse, and among these are the Rel-NF-
kappa B pathway components. NF-kappa B is a constitutive transcription factor, with a strong
presence in the brain of which a considerable part is located in the neuropiles. This
localization of the transcription factor, plus evidence pointing to different functions, is what
gave place to two general hypotheses for synaptic NF-kappa B:(a) The transcription factor
plays a role in the synapse to nucleus communication, and it is retrogradely transported from …