Allorecognition and effector pathways of islet allograft rejection in normal versus nonobese diabetic mice
L Makhlouf, A Yamada, T Ito, R Abdi… - Journal of the …, 2003 - journals.lww.com
Islet transplantation is becoming an accepted therapy to cure type I diabetes mellitus. The
exact mechanisms of islet allograft rejection remain unclear, however. In vivo CD4+ and
CD8+ T cell-depleting strategies and genetically altered mice that did not express MHC
class I or class II antigens were used to study the allorecognition and effector pathways of
islet allograft rejection in different strains of mice, including autoimmunity-prone nonobese
diabetic (NOD) mice. In BALB/c mice, islet rejection depended on both CD4+ and CD8+ T …
exact mechanisms of islet allograft rejection remain unclear, however. In vivo CD4+ and
CD8+ T cell-depleting strategies and genetically altered mice that did not express MHC
class I or class II antigens were used to study the allorecognition and effector pathways of
islet allograft rejection in different strains of mice, including autoimmunity-prone nonobese
diabetic (NOD) mice. In BALB/c mice, islet rejection depended on both CD4+ and CD8+ T …