A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

JP Ridge, F Di Rosa, P Matzinger - Nature, 1998 - nature.com
JP Ridge, F Di Rosa, P Matzinger
Nature, 1998nature.com
To generate an immune response, antigen-specific T-helper and T-killer cells must find each
other and, because they cannot detect each other's presence, they are brought together by
an antigen-loaded dendritic cell that displays antigens to both,,. This three-cell interaction,
however, seems nearly impossible because all three cell types are rare and migratory. Here
we provide a potential solution to this conundrum. We found that the three cells need not
meet simultaneously but that the helper cell can first engage and 'condition'the dendritic cell …
Abstract
To generate an immune response, antigen-specific T-helper and T-killer cells must find each other and, because they cannot detect each other's presence, they are brought together by an antigen-loaded dendritic cell that displays antigens to both,,. This three-cell interaction, however, seems nearly impossible because all three cell types are rare and migratory. Here we provide a potential solution to this conundrum. We found that the three cells need not meet simultaneously but that the helper cell can first engage and ‘condition’ the dendritic cell, which then becomes empowered to stimulate a killer cell. The first step (help) can be bypassed by modulation of the surface molecule CD40, or by viral infection of dendritic cells. These results may explain the longstanding paradoxical observation that responses to some viruses are helper-independent, and they evoke the possibility that dendritic cells may take on different functions in response to different conditioning signals.
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