[HTML][HTML] Immunocompetent T-cells with a memory-like phenotype are the dominant cell type following antibody-mediated T-cell depletion

JP Pearl, J Parris, DA Hale, SC Hoffmann… - American journal of …, 2005 - Elsevier
T-cell depletion facilitates reduced immunosuppression following organ transplantation and
has been suggested to be pro-tolerant. However, the characteristics of post-depletional T
cells have not been evaluated as they relate to tolerance induction. We therefore studied
patients undergoing profound T-cell depletion with alemtuzumab or rabbit anti-thymocyte
globulin following renal transplantation, evaluating the phenotype and functional
characteristics of their residual cells. Naïve T cells and T cells with potential regulatory …