[HTML][HTML] Deletion of autophagy-related 5 (Atg5) and Pik3c3 genes in the lens causes cataract independent of programmed organelle degradation
H Morishita, S Eguchi, H Kimura, J Sasaki… - Journal of Biological …, 2013 - ASBMB
The lens of the eye is composed of fiber cells, which differentiate from epithelial cells and
undergo programmed organelle degradation during terminal differentiation. Although
autophagy, a major intracellular degradation system, is constitutively active in these cells, its
physiological role has remained unclear. We have previously shown that Atg5-dependent
macroautophagy is not necessary for lens organelle degradation, at least during the
embryonic period. Here, we generated lens-specific Atg5 knock-out mice and showed that …
undergo programmed organelle degradation during terminal differentiation. Although
autophagy, a major intracellular degradation system, is constitutively active in these cells, its
physiological role has remained unclear. We have previously shown that Atg5-dependent
macroautophagy is not necessary for lens organelle degradation, at least during the
embryonic period. Here, we generated lens-specific Atg5 knock-out mice and showed that …
