Inhibition of sphingosine 1-phosphate receptor 2 protects against renal ischemia-reperfusion injury

SW Park, M Kim, KM Brown, VD D'Agati… - Journal of the American …, 2012 - journals.lww.com
Activation of the sphingosine 1-phosphate receptor 1 (S1P 1 R) protects against renal
ischemia-reperfusion (IR) injury and inflammation, but the role of other members of this
receptor family in modulating renal IR injury is unknown. We found that a selective S1P 2 R
antagonist protected against renal IR injury in a dose-dependent manner. Consistent with
this observation, both S1P 2 R-deficient mice and wild-type mice treated with S1P 2 R small
interfering RNA had reduced renal injury after IR. In contrast, a selective S1P 2 R agonist …